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KMID : 0921620130430030233
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Journal of Bacteriology and Virology
2013 Volume.43 No. 3 p.233 ~ p.234
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Resistance to Chemotherapy on Tumor Through Cathepsin B-dependent Activation of the NLRP3 Inflammasome
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Kwon Eun-Jeong
Koh Young-Sang
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Abstract
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Anticancer drugs kill tumor cells and increase host anti-tumor immunity. Interestingly, gemcitabin (Gem) and 5-fluorouracil (5-FU), widely used anticancer drugs, lead to IL-1β secretion releasing cathepsin B which activates Nlrp3 inflammasome in myeloid derived suppressor cells (MDSCs). MDSC derived IL-1β enhance secretion of IL-17 by CD4+ T cells. This mechanism limits the antitumor efficacy of the drugs and promotes tumor growth.
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KEYWORD
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Gemcitabin, 5-fluorouracil, MDSCs, Nlrp3 inflammasome
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